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SINGLE CELL Technology gradually replaces BULK TISSUE Sequencing, although with some limitations. An effort to reduce the noise in single cell technology using Bayesian Probabilistic method and Clustering Technology was done by BaySiCle:
Singh AN, Pal K (2023) BaySiCle: A Bayesian Inference Joint KNN Method for Imputation of Single-Cell RNA-Sequencing Data Making use of Local Effect. J Proteomics Bioinform.16:627.Â
https://www.longdom.org/open-access/baysicle-a-bayesian-inference-joint-knearest-neighbor-method-for-imputation-of-singlecell-rnasequencing-data-making-use-.pdf